H2N2V1, 1968, Analysis, bibRecord, 000056

Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses

Identifieur interne : 000056 ( 1968/Analysis ); précédent : 000055; suivant : 000057

Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses

Auteurs : Jens C. Krause [États-Unis] ; Tshidi Tsibane [États-Unis] ; Terrence M. Tumpey [États-Unis] ; Chelsey J. Huffman [États-Unis] ; Randy Albrecht [États-Unis] ; David L. Blum [États-Unis] ; Irene Ramos [États-Unis] ; Ana Fernandez-Sesma [États-Unis] ; Kathryn M. Edwards [États-Unis] ; Adolfo Garcia-Sastre [États-Unis] ; Christopher F. Basler [États-Unis] ; James E. Jr Crowe [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2012.

RBID : Pascal:12-0227810

Descripteurs français

KwdFr :
- ARN viral (génétique), Adulte, Adulte d'âge moyen, Analyse de survie, Analyse de séquence d'ADN, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (isolement et purification), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (isolement et purification), Anticorps monoclonaux (usage thérapeutique), Données de séquences moléculaires, Embryon de poulet, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (mortalité), Modèles animaux de maladie humaine, Mutation faux-sens, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (croissance et développement), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (croissance et développement), Sous-type H3N2 du virus de la grippe A (immunologie).
MESH :
- croissance et développement : Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- génétique : ARN viral.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- isolement et purification : Anticorps antiviraux, Anticorps monoclonaux.
- mortalité : Infections à Orthomyxoviridae.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Grippe humaine.
Pascal (Inist)
- Adulte, Adulte d'âge moyen, Analyse de survie, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Embryon de poulet, Femelle, Homme, Anticorps monoclonal, Grippe, Humains, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Mutation faux-sens, Souris, Souris de lignée BALB C.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Animals, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (isolation & purification), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (isolation & purification), Antibodies, Viral (therapeutic use), Chick Embryo, Disease Models, Animal, Female, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Human, Humans, Influenza, Influenza A Virus, H2N2 Subtype (growth & development), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (growth & development), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (immunology), Influenza, Human (virology), Mice, Mice, Inbred BALB C, Middle Aged, Molecular Sequence Data, Monoclonal antibody, Mutation, Missense, Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (prevention & control), RNA, Viral (genetics), Sequence Analysis, DNA, Survival Analysis.
MESH :
- chemical , genetics : RNA, Viral.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , isolation & purification : Antibodies, Monoclonal, Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- growth & development : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human.
- mortality : Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- virology : Influenza, Human.
- Adult, Animals, Chick Embryo, Disease Models, Animal, Female, Humans, Mice, Mice, Inbred BALB C, Middle Aged, Molecular Sequence Data, Mutation, Missense, Sequence Analysis, DNA, Survival Analysis.

Abstract

Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V_H1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372199

Affiliations:

Links to Exploration step

Pascal:12-0227810

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses</title>
<author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name>
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<author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name>
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<author><name sortKey="Huffman, Chelsey J" sort="Huffman, Chelsey J" uniqKey="Huffman C" first="Chelsey J." last="Huffman">Chelsey J. Huffman</name>
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<author><name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
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<placeName><region type="state">État de New York</region>
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</author>
<author><name sortKey="Blum, David L" sort="Blum, David L" uniqKey="Blum D" first="David L." last="Blum">David L. Blum</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, Vanderbilt University Medical Center</s1>
<s2>Nashville, Tennessee</s2>
<s3>USA</s3>
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<sZ>9 aut.</sZ>
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<placeName><region type="state">Tennessee</region>
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</affiliation>
</author>
<author><name sortKey="Ramos, Irene" sort="Ramos, Irene" uniqKey="Ramos I" first="Irene" last="Ramos">Irene Ramos</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Microbiology, Mount Sinai School of Medicine</s1>
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<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Microbiology, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
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<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, Vanderbilt University Medical Center</s1>
<s2>Nashville, Tennessee</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="Garcia-Sastre">Adolfo Garcia-Sastre</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Microbiology, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F." last="Basler">Christopher F. Basler</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Microbiology, Mount Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crowe, James E Jr" sort="Crowe, James E Jr" uniqKey="Crowe J" first="James E. Jr" last="Crowe">James E. Jr Crowe</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, Vanderbilt University Medical Center</s1>
<s2>Nashville, Tennessee</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Vanderbilt University Medical Center</s1>
<s2>Nashville, Tennessee</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Antibodies, Monoclonal (isolation & purification)</term>
<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibodies, Viral (isolation & purification)</term>
<term>Antibodies, Viral (therapeutic use)</term>
<term>Chick Embryo</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Human</term>
<term>Humans</term>
<term>Influenza</term>
<term>Influenza A Virus, H2N2 Subtype (growth & development)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (growth & development)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Monoclonal antibody</term>
<term>Mutation, Missense</term>
<term>Orthomyxoviridae Infections (mortality)</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>RNA, Viral (genetics)</term>
<term>Sequence Analysis, DNA</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps antiviraux (isolement et purification)</term>
<term>Anticorps antiviraux (usage thérapeutique)</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Anticorps monoclonaux (isolement et purification)</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Données de séquences moléculaires</term>
<term>Embryon de poulet</term>
<term>Femelle</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (mortalité)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mutation faux-sens</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H2N2 du virus de la grippe A (croissance et développement)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (croissance et développement)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
</keywords>
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<term>Anticorps monoclonaux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Grippe humaine</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Chick Embryo</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Mutation, Missense</term>
<term>Sequence Analysis, DNA</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Embryon de poulet</term>
<term>Femelle</term>
<term>Homme</term>
<term>Anticorps monoclonal</term>
<term>Grippe</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mutation faux-sens</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V<sub>H</sub>
1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
<li>Tennessee</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name>
</region>
<name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
<name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
<name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F." last="Basler">Christopher F. Basler</name>
<name sortKey="Blum, David L" sort="Blum, David L" uniqKey="Blum D" first="David L." last="Blum">David L. Blum</name>
<name sortKey="Crowe, James E Jr" sort="Crowe, James E Jr" uniqKey="Crowe J" first="James E. Jr" last="Crowe">James E. Jr Crowe</name>
<name sortKey="Crowe, James E Jr" sort="Crowe, James E Jr" uniqKey="Crowe J" first="James E. Jr" last="Crowe">James E. Jr Crowe</name>
<name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
<name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
<name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="Garcia-Sastre">Adolfo Garcia-Sastre</name>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="Garcia-Sastre">Adolfo Garcia-Sastre</name>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="Garcia-Sastre">Adolfo Garcia-Sastre</name>
<name sortKey="Huffman, Chelsey J" sort="Huffman, Chelsey J" uniqKey="Huffman C" first="Chelsey J." last="Huffman">Chelsey J. Huffman</name>
<name sortKey="Ramos, Irene" sort="Ramos, Irene" uniqKey="Ramos I" first="Irene" last="Ramos">Irene Ramos</name>
<name sortKey="Tsibane, Tshidi" sort="Tsibane, Tshidi" uniqKey="Tsibane T" first="Tshidi" last="Tsibane">Tshidi Tsibane</name>
<name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses
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Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses

Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses

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